Association between Polymorphism of S2 Locus Allele in ADAM33 Gene and Bronchial Asthma in Xinjiang Uygur Population_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

SANG Ke , HU Xin , WANG Qiong , QIMANGULI Wushouer.

Department of Pulmonary Medicine, The First Affiliated Hospital to Xinjiang Medical University. Urumqi, Xinjiang, 830054,ChinaCorresponding Author: QIMANGULI Wushouer, E-mail: qimenw@ hotmail. com;

Corresponding author：

Keywords：

Bronchial asthma; ADAM33 gene; Allele; Single nueleotide polymorphis

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130106

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Objective To investigate the association between polymorphism of S2 locus allele in ADAM33 gene and bronchial asthma in Xinjiang Uygur population.
Methods PCR-RFLP was used to determine polymorphismof S2 locus allele in ADAM33 gene in 131 Uygur patients with bronchial asthma ( asthma group) and 90 Uygur healthy individuals ( control group) .
Results The comparison of three genotypes and allele frequency of the S2 in the ADAM33 gene had statistical significance in the asthma group and the control group ( X2 =6. 065, P lt;0. 05;X2=5. 255, P lt;0. 025) . The G allele of S2 site increased the risk of asthma( OR =1. 616, P lt;0. 05) . The CG genotype also increased the risk of asthma ( OR= 1. 351,P lt;0. 05) . The FEV1% pred and FVC% pred had significant difference between three genotypes of the S2 site in the ADAM33 gene in the asthma group ( F = 6. 248, P lt; 0. 01; F = 7. 067, P lt; 0. 01) .
Conclusion The polymorphism of the S2 site in the ADAM33 gene has significant correlation with asthma in Xinjiang Uygur population, and can increase risk of asthma in the Uygur population.

Citation： SANG Ke,HU Xin,WANG Qiong,QIMANGULI Wushouer.. Association between Polymorphism of S2 Locus Allele in ADAM33 Gene and Bronchial Asthma in Xinjiang Uygur Population. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(5): 442-445. doi: DOI: 10 . 7507 /1671 -6205 . 20130106 Copy

1.	Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2.	Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3.	中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南. 中华结核和呼吸杂志, 2008, 31 : 177-185.
4.	Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5.	Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7.	迟翔宇, 王学群, 王来城, 等. 支气管哮喘患者ADAM33 基因S2位点多态性的研究. 临床内科杂志, 2011, 28 : 47-49.
8.	Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9.	de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10.	Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11.	Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12.	Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13.	Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14.	Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15.	Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16.	Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17.	Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18.	Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19.	, 84: 203-210 .

1. Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Crenet, 2000, 16: 83 -87 .
2. Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.Nature, 2002, 418 : 426-430.
3. 中华医学会呼吸病学分会哮喘学组. 支气管哮喘防治指南. 中华结核和呼吸杂志, 2008, 31 : 177-185.
4. Yoshinaka T, Nishii K, Yamada K, et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity. Gene, 2002, 282( 1 /2) : 227-236.
5. Dijkstra A, Vonk JM, Jongepier H, et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex.Thorax, 2006 , 61: 105-110.
6. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
7. 迟翔宇, 王学群, 王来城, 等. 支气管哮喘患者ADAM33 基因S2位点多态性的研究. 临床内科杂志, 2011, 28 : 47-49.
8. Awasthi S, Tripathi P, Husain N, et al. Association of ADAM33 gene polymorphisms with asthma in Indian children. JHum Genet,2011, 56: 188-195 .
9. de Faria IC, de Faria EJ, Toro AA, et al. Association of TGFbeta1,CDl4, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. J Pediatr ( Rio J) ,.
10. Matsusue A, Kiyohara C, Tanaka K, et al. ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. Clin Biochem, 2009, 42: 477-483.
11. Lind DL, Choudhry S, Ung N, et al. ADAM 33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med, 2003 , 168: 1312-1316.
12. Lee JH, Park HS, Park SW, et al. ADAM33 polymorphism:association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy, 2004, 34: 860-865 .
13. Kedda MA, Duffy DL, Bradley B, et al. ADAM33 haplotypes are associated with asthma in a large Australian population. Eur J Hum Genet, 2006 , 14 : 1027-1036.
14. Hirota T, Hasegawa K, Obara K, et al. Association between ADAM33 polymorphisms and adult asthma in the Japanese population. Clin Exp Allergy, 2006, 36: 884 -891.
15. Foley SC, Mogas AK, Olivenstein R, et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol, 2007 , 119: 863-871.
16. Sakagami T, Jinnai N, Nakajima T, et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet, 2007, 52: 66-72 .
17. Tripathi P, Awasthi S, Prasad R, et al. Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population. J Genet, 2011, 90: 265-273.
18. Fang Q, Zhao H, Wang A, et al. Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han Population. BMC Med Genet, 2011, 12: 133.
19. , 84: 203-210 .

Chinese Journal of Respiratory and Critical Care Medicine

Association between Polymorphism of S2 Locus Allele in ADAM33 Gene and Bronchial Asthma in Xinjiang Uygur Population

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